Evaluating the Effect of Topical Lidocaine Spray Versus Dexmedetomidine Spray on Suppression of Stress Response to Laryngoscopy and Endotracheal Intubation: a Randomized Controlled Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- To measure systolic blood pressure immediately after intubation.
研究概览
简要总结
Many studies discussed attenuating stress response by various measures but to the interest of our study , No one compared topical spray of both lidocaine and dexmedetomidine in attenuating the haemodynamic stress responses of laryngoscopy and endotracheal intubation, avoiding undesired systemic effects of drugs ,
详细描述
This study will be conducted in the operating theatres of Cairo university hospitals.
Patients undergoing any surgery under general anesthesia and needs endotracheal intubation using direct laryngoscopy will be assigned to one of the three groups:
Group C: will receive 5ml of normal saline sprayed via long nostril syringe into oropharynx, the vocal cords and tracheobronchial tree 5 minutes before intubation Group L: : will receive 5ml of lidocaine 2% (100mg) sprayed via long nostril syringe into oropharynx , the vocal cords and tracheobronchial tree 5 minutes before intubation Group D: : will receive dexmedetomidine (1 μg/kg) diluted in 5ml normal saline sprayed via long nostril syringe into oropharynx , the vocal cords and tracheobronchial tree 5 minutes before intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• ASA I,II
- •Age 18-60y
- •Patients scheduled for any operations under general anesthesia and needs endotracheal intubation using direct laryngoscopy in the operating theatre.
排除标准
- •• Uncontrolled high blood pressure > 160/100 heart disease in the form of ischemic heart disease and severe valvular disease.
- •Patients with the history of allergy to lidocaine or dexmedetomidine.
- •ASA III & IV.
- •Patients refuse to share in this study
- •Suspected difficult intubation that needs more than 2 trials.
研究组 & 干预措施
Group C
Group C: will receive 5ml of normal saline sprayed via long nostril syringe into oropharynx, the vocal cords and tracheobronchial tree 5 minutes before intubation
干预措施: Normal saline, Lidocaine, dexmetomidine (Drug)
Group L
: : will receive 5ml of lidocaine 2% (100mg) sprayed via long nostril syringe into oropharynx , the vocal cords and tracheobronchial tree 5 minutes before intubation
干预措施: Normal saline, Lidocaine, dexmetomidine (Drug)
Group D
will receive dexmedetomidine (1 μg/kg) diluted in 5ml normal saline sprayed via long nostril syringe into oropharynx , the vocal cords and tracheobronchial tree 5 minutes before intubation.
干预措施: Normal saline, Lidocaine, dexmetomidine (Drug)
结局指标
主要结局
To measure systolic blood pressure immediately after intubation.
时间窗: Immediately after endotracheal intubation
Using invasive blood pressure monitoring
次要结局
未报告次要终点
研究者
Dina Mahmoud Mohamed
Lecturer of Anesthesia and Surgical ICU and pain management
Kasr El Aini Hospital