CTRI/2023/10/059088尚未招募Unknown
Total NEOadjuvant therapy in locally advanced carcinoma rectum with short course simultaneous integrated BOOST radiotherapy (NEO-BOOST Trial): A Single Center Prospective Pilot Study
Chittaranjan National Cancer Institute (CNCI)0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Age >18 years and <75 years
- •2. Biopsy proven locally advanced adenocarcinoma of rectum
- •3. ECOG PS 0-2
- •4. Colonoscopy with tumour <16cm from anal verge
- •5. Pelvic MRI with atleast one of the high risk features e.g. high tumour stage (cT4a or cT4b) and/ or high nodal stage (cN2 or more) and/ or extramural vascular invasion and/ or involved mesorectal fascia by tumour or lymph node
- •6. Acceptable laboratory parameters with hemoglobin level > 8.5 gm%, white blood cell count > 4000/cc, platelet count > 1,00,000/ cc, creatinine clearance > 50ml/min and bilirubin level <2 mg%
- •7. Physically and mentally fit for the treatment and follow up
排除标准
- •1. ECOG PS 3-4
- •2. Age <18 years or > 75 years
- •3. Extensive growth of the rectal tumour into the cranial part of the sacrum or the lumbosacral nerve roots indicating that surgery will never be possibleeven if substantial tumour downsizing is seen and presence of metastatic disease or recurrent rectal cancer.
- •4. Any prior treatment for cancer
研究者
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