Comparison of preoperative magnesium sulphate versus dexmedetomidine nebulisation for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in severe preeclampsia parturients undergoing caesarean section: A Randomised clinical study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To assess changes in hemodynamic parameters like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure
研究概览
简要总结
Laryngoscopy and endotracheal intubation cause significant sympathetic stimulation, resulting in tachycardia and hypertension, responses that are exaggerated and potentially hazardous in severe preeclampsia due to already elevated vascular resistance. This randomised clinical study aims to compare the efficacy of preoperative nebulization with inj magnesium sulphate 40mg/kg versus preoperative nebulization with inj dexmedetomidine 1 microgram/kg in attenuating the pressor response during induction and intubation in preeclamptic parturients scheduled for caesarean section. Patient will be divided in two groups, Group D receiving inj dexmedetomidine nebulization and Group M receiving inj magnesium Sulphate nebulization. Patient is assessed for changes in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure in peri-intubation period. This study will help us to compare efficacy of both of these agents in attenuating the hemodynamic response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Female
入选标准
- •Parturients with severe preeclampsia undergoing caesarean section under general anaesthesia with asa physical status 1 and 2.
排除标准
- •ASA status more than 2 2) Mallampati grade more than 2 3) Allergic to study drug 4) Anticipated difficult intubation 5) Requiring more than 2 attempts at intubation 6)BMI 40 or more than 40kg/m2 7) Comorbidities 8) Emergency Caesarean section 9) Consent not given to participate in clinical study.
结局指标
主要结局
To assess changes in hemodynamic parameters like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure
时间窗: Assessed before nebulization, after completion of nebulization, at the time of laryngoscopy and intubation, at 1 min, 2min, 3min, 4min, 6min, 8min, 10min after intubation.
次要结局
- Cough at time of extubation(At the time of extubation)
- Post operative sore throat(At time of extubation, at 6hr post extubation and at 12hr post extubation)
- Side effects of drug
研究者
Dr Arvind Khare
Jawahar lal Nehru Medical College