Resistance Training for Life - the Efficacy of Increasing Resistance Training Volume for Improving Muscle Mass, Function, Biology and Health in Young and Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 2
- 主要终点
- Muscle size, lower extremities
研究概览
简要总结
Sarcopenia is an age-related gradual loss of muscle mass and strength and is associated with physical disability and mortality risk. Currently, the most promising remedy for preventing and treating sarcopenia is physical activity, particularly progressive resistance training. Yet, the amount of resistance exercise needed to achieve optimal benefits remains largely unknown. This lack of knowledge is underpinned by the notion that aging reduces the ability to adapt to (and benefit from) resistance training, and is further complicated by a relative large degrees of between-subject heterogeneity. The primary aim of the study is to compare the effects of 10 weeks of resistance training with low- and moderate volume (one vs. three sets per exercise) on muscle mass accretion in lower and upper body extremities in young (<30 years of age) and elderly individuals (>70 years of age). Specifically, the study addresses the hypothesis that elderly individuals will benefit more from higher exercise volume (moderate vs. low) compared to their young counterparts. In addition, the study aims to compare the efficacy of the two volume conditions for altering other characteristics such as muscle strength and biology, including assessment of associations between individual changes in muscle mass, strength and biology (e.g. the relationship between muscle mass accretion and muscle content of rRNA/rDNA), and also to investigate the general health effects of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Study conditions (exercise volume) and age groups identifiers are omitted from outcome assessments whenever possible. Assessment of the primary (and selected secondary) outcome(s) will be performed in a blinded fashion by assessors/investigators.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages between 18 and 30 or > 70
排除标准
- •Resistance training, > 1 session per week
- •Endurance training, > 3 sessions per week
- •Unstable cardiovascular disease
- •Illness or serious injury contradicting resistance training
- •Serious mental illness
- •Allergy to local anaesthesia
结局指标
主要结局
Muscle size, lower extremities
时间窗: Change from baseline to after the training period (10-12 weeks)
Muscle size of lower extremity knee extensors measured with magnetic resonance imaging (MRI).
次要结局
- Muscular peak power/force, lower-body extremities(MeasurChange from baseline to after the training period (10-12 weeks))
- Muscle size, upper-body extremities(Change from baseline to after the training period (10-12 weeks))
- Appendicular lean mass, lower-body extremities(Change from baseline to after the training period (10-12 weeks))
- Appendicular lean mass, upper-body extremities(Change from baseline to after the training period (10-12 weeks))
- Muscle thickness, m. vastus lateralis(Change from baseline to after the training period (10-12 weeks))
- Muscle strength, lower-body extremities(Change from baseline to after the training period (10-12 weeks))
- Muscle strength, upper-body extremities(Change from baseline to after the training period (10-12 weeks))
研究者
Stian Ellefsen
Professor
Inland Norway University of Applied Sciences