NCT01126684已完成不适用
EFFECTS OF ATORVASTATIN ON BLOOD PRESSURE AND URINARY ALBUMIN EXCRETION IN PATIENTS WITH ESSENTIAL HYPERTENSION
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Ambulatory blood pressure
研究概览
简要总结
To evaluate the possible effects of atorvastatin on ambulatory blood pressure, urinary albumin excretion, insulin resistance and arterial stiffness in hypertensive patients, beyond those on lipid profile. Glycemic parameters, "novel" cardiovascular risk factors and safety parameters will be also evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •LDL-C>130 or >160 mg/dL (depending on the total risk according to the most recent recommendations25).
- •no previous hypolipidemic medication
- •ability to provide Informed Consent.
排除标准
- •pregnancy or lactation
- •myocardial infarction or unstable angina within the past 6 months
- •heart failure NYHA class III-IV
- •renal disease (SCr>3 mg/dL or proteinuria>3g/d)
- •liver disease
- •history of malignancy
- •history of drug or alcohol abuse
- •treatment with corticosteroids
- •any other condition with poor prognosis
- •inability to provide Informed Consent.
研究组 & 干预措施
Atorvastatin
Active Comparator
干预措施: Atorvastatin (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Ambulatory blood pressure
时间窗: Six months
次要结局
- Urinary Albumin Excretion(Six months)
- Insulin Sensitivity(Six months)
- Arterial Stiffness(Six months)
- Urinary levels of nephrin(Six months)
- Urinary levels of podocalyxin(Six months)
- Urinary levels of Endothelin-1(Six months)
- Urinary levels of Asymmetric Dimethylarginine(Six months)
- Urinary levels of indices of oxidative stress(Six months)
研究者
研究点 (1)
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