Endometrial Dating by Ex-vivo Imaging of Endometrial Biopsies of In-vitro Fertilization Candidate Participants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Correlation between image-based endometrial dating and that of histology
研究概览
简要总结
To evaluate the correlation between cycle day determination by clinical signs, study participant testimony, endometrium histopathology biopsy and ex-vivo imaging of the uterus endometrium.
详细描述
In order to assess the efficacy of using ex-vivo endometrial imaging to determine optimal time for embryo transfer, two to four separate analyses, including imaging, and the current standard method of endometrial dating (ultrasound, histological and blood tests) will be performed as well as participant's testimony. Dating by hormonal profile (blood tests) will be contingent on availability of the tests for each subject. So shall be the ultrasound test. During the analysis data will be acquired for subsequent correlation analysis. In addition, a parallel in-vivo analysis, similar in methodology to the ex-vivo analysis, may be performed via imaging by hysteroscopy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gender: Female
- •Belong to one of the three following groups:
- •Women undergoing fertility treatment, and are regularly ovulating
- •Women whose fertility status is unknown
- •Women proved to be fertile (previous spontaneous successful pregnancy)
排除标准
- •Women with known existing endometrial pathology
- •Women with known history of infertility due to oligo-ovulation or anovulation.
- •Women with medical history of malignant tumors in their reproductive system
- •Women that are on any hormonal medications or treatments (excluding hormonal contraception in previous cycles)
- •Women that are on hormonal contraception treatment in their current cycle
- •Women with intrauterine device
- •Women menstruating on the day of the biopsy collection
结局指标
主要结局
Correlation between image-based endometrial dating and that of histology
时间窗: 12 months
Correlation coefficients and/or P-value levels
次要结局
- Correlation between image-based endometrial dating and other collected data(12 months)