Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
研究概览
简要总结
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.
详细描述
Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants will undergo a stripping operation for varicose veins
- •Surgery will be performed by one physician only
- •Written informed consent
排除标准
- •Any contraindications to the proposed interventions
- •Procedures done under regional anesthesia
研究组 & 干预措施
1
Patients will receive propofol anesthesia during varicose vein stripping surgery.
干预措施: propofol (Drug)
2
Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.
干预措施: sevoflurane (Drug)
结局指标
主要结局
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
时间窗: first post operative morning
次要结局
- To determine the average pain score for each group during the first four hours of recovery after surgery.(30 minute intervals for first 4 hours post operatively)