NCT01922973已完成不适用
Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 主要终点
- Ghrelin concentration
研究概览
简要总结
The overall objective of this study is to determine the extent to which circulating ghrelin levels (total and bioactive ghrelin) are regulated by nutritional state and age.
详细描述
Normal volunteers: young and older men and women studied under fed and fasting (total 62.5h) conditions, frequent blood sampling for ghrelin and other related hormones
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy young (ages 18-30) and older (ages > 60) men and women with a body mass index (BMI) of <35 kg/m
- •Young and older subjects will be matched for BMI.
排除标准
- •A history of coronary artery disease, congestive heart failure, peripheral vascular disease, diabetes mellitus, significant hypertension (BP >180 systolic or >100 diastolic at rest); renal, hepatic, pulmonary disease; untreated hypothyroidism, untreated hyperthyroidism; history of seizure disorder; history of malignancy (other than some skin cancers), history of active chronic infections (e.g., HIV, tuberculosis): abnormal screening laboratory tests. This information will be obtained through the use of screening labs, history and physical exam and the medical record. See the GCRC protocol for details of the labs.
- •Hematocrit < 41% men, < 38% women
- •History of daily tobacco use within past 3 months
- •Chronic alcohol abuse
- •Recent weight change of > 10 pounds in last 3 months
- •Strenuous exercise for average of more than 60 min/day
- •Investigational drug within past 6 weeks
- •Any history of major psychosis, severe depression, anorexia nervosa
- •Transmeridian travel within 2 weeks prior to or during study -
结局指标
主要结局
Ghrelin concentration
时间窗: 24-h mean
次要结局
未报告次要终点
研究者
Michael Thorner, MD
Professor of Medicine
University of Virginia
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