Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Nitrous oxide and chronic pain
研究概览
简要总结
The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups.
详细描述
The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18 to 65 years old at time of the first procedure
- •American Society of Anesthesiologists physical status I or II
- •Hysterectomy undergoing the general anesthesia
排除标准
- •Neuropathic disease
- •Chronic opioid users
- •Contraindication for Nitrous Oxide receive
- •Consent will not be obtained patient
- •Psychiatric disorders
- •Current or recent drug abuse (within past 6 months).
研究组 & 干预措施
General anesthesia with oxygen
General anesthesia and Air
干预措施: General anesthesia with oxygen (Other)
nitrous oxide and general anesthesia
General anesthesia with Nitrous Oxide
干预措施: Nitrous oxide (Drug)
结局指标
主要结局
Nitrous oxide and chronic pain
时间窗: 30 days post operative
The of the effect of 50% N20/50% O2 on post hysterectomy in prevention of chronic pain.
Nitrous oxide and opioid consumption
时间窗: 4 hours post operative
The effect of 50% N20/50% O2 on post hysterectomy in decrease of opioid consumption.
次要结局
未报告次要终点
研究者
Alparslan Turan
Principal Investigatgor
The Cleveland Clinic