NCT02103842已完成1 期
Omega-3 Fatty Acids to Combat Sarcopenia
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Change in Muscle protein synthesis
研究概览
简要总结
The purpose of this study is to determine how omega-3 fatty acids influence muscle protein metabolism and mitochondrial physiology in the context of human aging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-35 or 65-85 years
排除标准
- •Current use of omega-3 nutritional supplements
- •Fasting plasma glucose ≥126 mg/dL
- •Active coronary artery disease
- •Participation in structured exercise (>3 times per week for 30 minutes or longer)
- •Medications known to affect muscle metabolism (e.g., beta blockers, corticosteroids, tricyclic-antidepressants, benzodiazepines, opiates, barbiturates, anticoagulants)
- •Renal failure (serum creatinine > 1.5mg/dl)
- •Chronic active liver disease (Bilirubin > 17mmol/L, AST>144IU/L, or ALT>165IU/L)
- •Anti-coagulant therapy (warfarin/heparin)
- •Use of systemic glucocorticoids
- •Chronic use of NSAIDS or aspirin
- •Pregnancy or breastfeeding
- •Alcohol consumption greater than 2 glasses/day
- •Hypothyroidism
- •Fish or shellfish allergy
研究组 & 干预措施
Omega-3 fatty acids
Experimental
Participants will take 3.9g/day of Eicosapentaenoic acid and docosahexaenoic acid for 4 months
干预措施: Omega-3 fatty acids (Drug)
结局指标
主要结局
Change in Muscle protein synthesis
时间窗: Baseline and following 4 months intervention
Skeletal muscle protein synthesis will be measured from the rate of incorporation of infused amino acids measured by mass spectrometry.
Change in Muscle mitochondrial function
时间窗: Baseline and following 4 months intervention
Mitochondrial function will be measured in isolated mitochondria by high-resolution respirometry.
次要结局
未报告次要终点
研究者
研究点 (1)
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