The Influence of Propofol and Sevoflurane on Hemostasis During Ophthalmic Surgery: Rotational Thromboelastographic Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Clotting time of ROTEM
研究概览
简要总结
We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patient scheduled for ophthalmic surgery under general anesthesia
- •American Society of Anesthesiologist physical status I or II
排除标准
- •hematologic disorder
- •severe anemia
- •liver disease
- •kidney disease
- •taking a medication interfering with hemostasis
研究组 & 干预措施
Total intravenous anesthesia group
This group received propofol and remifentanil for the maintenance of general anesthesia.
干预措施: Propofol, remifentanil (Drug)
Inhalation anesthesia group
This group received sevoflurane for the maintenance of general anesthesia.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Clotting time of ROTEM
时间窗: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Clot firmness time of ROTEM
时间窗: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Alpha angle of ROTEM
时间窗: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Maximum clot firmness of ROTEM
时间窗: 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
次要结局
- Hemoglobin(10 minutes before the induction of anesthesia)
- Hematocrit(10 minutes before the induction of anesthesia)
- Platelet count(10 minutes before the induction of anesthesia)
- International normalized ratio of prothrombin time(10 minutes before the induction of anesthesia)
- Activated partial thromboplastin time(10 minutes before the induction of anesthesia)
- Fibrinogen(10 minutes before the induction of anesthesia)
研究者
Hyo-Seok Na
Pf
Seoul National University Bundang Hospital