NCT05230433已完成不适用
Implications of Insulin Resistance and Cardiorespiratory Fitness in the Metabolic Response to a High-fat Meal Challenge in Pediatrics
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Palatability of the High Fat Agent.
研究概览
简要总结
The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 8 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children ages 8-17 years with a BMI-percentile ≥ 5th.
排除标准
- •Previous diagnosis of type 1 or 2 diabetes.
- •Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin).
- •Evidence of inherited disorders of lipid metabolism.
- •Inability to participant in the maximal aerobic capacity test on the treadmill.
- •Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy.
- •Individuals who cannot speak and/or write in English.
结局指标
主要结局
Palatability of the High Fat Agent.
时间窗: 10 minutes
Determine the number of participants that complete at least 75% of the shake (by weight).
次要结局
- BMI Percentile(At baseline)
- Medium Chain Acylcarnitine Concentration(60 and 180 minutes post consumption of high fat shake)
- Fold Change of Medium Chain Acylcarnitine at 60 and 180 Minutes.(60 and 180 minutes post consumption of high fat shake)
研究者
Jennifer L. Meijer
Principal Investigator; Scientist
Dartmouth-Hitchcock Medical Center
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin ResistanceInsulin ResistanceNCT00954109US Department of Veterans Affairs11
终止
不适用
Effect of Exercise on Insulin ResistancePrediabetic StateNCT01941277Alere San Diego3
已完成
不适用
Fitness Training in ChildrenLow FitnessObesityNCT00205296University of Wisconsin, Madison300
已完成
不适用
Aerobic Plus Resistance Training and Insulin Sensitivity in African American MenType 2 DiabetesInsulin ResistanceNCT01787617Pennington Biomedical Research Center113
已完成
不适用
Exercise Intensity, Metabolic Rate and Insulin SensitivityHealthy WomenNCT01879891University of Alabama at Birmingham44