Dexmedetomidine Versus Dexamethasone as an Additive to Local Anesthetic Mixture in Peribulbar Block in Cataract Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Time for first request of the rescue analgesia
研究概览
简要总结
This study aimed to compare the effects of dexamethasone and dexmedetomidine when added to a local anesthetic mixture for peribulbar block in patients undergoing elective anterior segment eye surgery.
详细描述
Regional block (especially peribulbar block) is the preferred choice of anesthesia for many ophthalmic surgeries as it has less complications. Peribulbar block with local anesthetics only lead to delayed onset corneal anesthesia and globe akinesia, and frequent need of block supplementation.
Dexmedetomidine is a drug which belongs to alpha 2 adrenergic receptor agonist. It provides several desirable effects, including sedation, anxiolysis, analgesia, and a reduction in intraoperative opioid requirements, when used as an adjuvant to local anesthetics, dexmedetomidine has been shown to prolong the duration of sensory and motor blocks, improve hemodynamic stability, and enhance overall patient satisfaction.
Dexamethasone, a synthetic corticosteroid, the use of dexamethasone as an additive in peribulbar blocks has been shown to improve the quality of anesthesia, reduce the need for supplemental intraoperative analgesics, and decrease postoperative pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: > 18 years old.
- •Sex: Male & Female
- •American Society of Anesthesiologists (ASA) Physical status I -III.
- •Patients undergoing ophthalmic surgery under local anesthesia.
排除标准
- •Patients' refusal.
- •Patients have active ocular infection.
- •Patients have single eyes.
- •Allergy to thesis medications (mainly bupivacaine and lidocaine).
- •Patients cannot lie flat.
- •Patient on anticoagulation.
- •Abnormal coagulation profile in the form of international normalized ratio (INR) ≥1.6
结局指标
主要结局
Time for first request of the rescue analgesia
时间窗: 24 hours postoperatively
Time for first request of the rescue analgesia was recorded from the end of surgery till first dose of morphine administrated.
次要结局
- Mean arterial blood pressure(12 hours postoperatively)
- Postoperative opioid consumption(12 hours postoperatively)
- Degree of patient satisfaction(24 hours postoperatively)
- Degree of pain(12 hours postoperatively)
- Heart rate(12 hours postoperatively)
- Intraocular pressure(10 min after injection of local anesthetics)
研究者
Sameh Ashraf Mandouh
Resident of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Helwan University, Egypt.
Helwan University