NL-OMON30568已完成不适用
Cerebrovascular dysfunction in Alzheimer and mild cognitive impairment. - Cerebrovascular dysfunction in Alzheimer and MCI
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Alzheimer patients
- •Alzheimer diagnosed according to the DSM-IV criteria for dementia (American Psychiatric Association, 1994), and NINCDS-ADRDA criteria (McKhann et al., 1984)(probable, possible).
- •Presence of a reliable informant, who has contact with the patient at least once a week.
- •Informed consent of the patient before participation into the study.;MCI patients
- •The descriptions proposed by Petersen et al. (1999) are used to classify MCI.
- •Informed consent of the patient before participation into the study.;Controls
- •Informed consent before participation into the study.
- •Control matching parameters will be age, sex and level of education.
排除标准
- •Alzheimer patients
- •If living in a nursing home at the start of the study.
- •Patients without a reliable informant.
- •Diagnosis of Vascular Dementia, according to NINDS/AIREN criteria (Roman et al., 1993)
- •Presence of micro-vascular pathology as defined by the Fazekas scale (Fazekas, 1987)
- •Use of psychopharmacological medication.
- •Abuse of alcohol and/or drugs.
- •Heart disease
- •Presence of hypertension will be considered as a co-variate in the analysis.;To exclude patients with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects. Patients without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 Alzheimer patients will have to be screened to acquire a group of 20 subjects.;MCI patients
- •If living in a nursing home at the start of the study.
- •Use of psychopharmacological medication.
- •Abuse of alcohol and/or drugs.
- •Heart disease
- •Presence of hypertension will be considered as a co-variate.;To exclude patients with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects.
- •Patients without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 MCI patients will have to be screened to acquire a group of 20 subjects.
- •Use of psychopharmacological medication.
- •Abuse of alcohol and/or drugs.
- •Heart disease;To exclude participants with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects.
- •Participants without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 controls will have to be screened to acquire a group of 20 subjects
- •Control matching parameters will be age, sex and level of education.
- •Presence of hypertension will be considered as a co-variate.
研究者
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