Microvascular lesions in the brain in Alzheimer*s disease: identification of a novel biomarker with 7T MRI

Completed

• Conditions: Alzheimer Disease; Dementia; 10042258; 10047075

• Registration Number: NL-OMON36418
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Participant of *parelsnoer neurodegeneratieve ziekten* project and diagnosed with (possible) Alzheimer's disease.;For parelsnoer:
referred to memory clinic
subjective and/or objective cognitive impairment
CDR 0, 0.5 or 1
MMSE 20 or higher

Exclusion Criteria

Normal pressure Hydrocephalus, M. Huntington
Recent CVA (<2 years), or CVA with subsequent (within 3 months) cognitive deterioration
(History of) Schizophrenia, other psychotic disorders
Major depression
Alcohol abuse
Brain tumour, epilepsia, encephalitis
Absence of reliable informant
Expectation that patient can not be followed for at least 1 year.
Contra-indication for 7 Tesla MR imaging

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence and total number of microinfarcts at 7T<br /><br>The prevalence and total number of microbleeds at 7T<br /><br><br /><br>For the parelsnoer project participants will already receive a full clinical<br /><br>assessment, neuropsychological tests and a 3T MRI.<br /><br>Participants in the present study will also undergo some additional<br /><br>neuropsychological tests and a 7T MRI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Conventional brain MRI markers of AD (atrophy) and vascular lesions (large<br /><br>infarcts, white matter hyperintensities) at 3T MRI<br /><br>• Cognitive profile<br /><br>• Vascular risk factor profile</p><br>