Comparative Evaluation Of Injectable - Platelet Rich Fibrin And Hyaluronic Acid with Microneedling In Thin Gingival Phenotype - A Split Mouth Study

Depending on the size, texture, location, and shape of the gingiva and alveolar process, each person has a distinct “Gingival Phenotype” that affects their periodontal response to inflammation and course of therapy.Individuals with thin-phenotype are more likely to experience gingival recession in the context of trauma and inflammation.Conventionally, surgical techniques like subepithelial connective tissue grafting and other augmentation procedures such as modified roll technique and acellular dermal matrix were found to be useful .Since patients are reluctant in doing surgical procedures, it has come  for the need of non-surgical therapies to enhance the gingival phenotype.Thus Microneedling, I-PRF and hyaluronic acid has been found to be an alternative choice for the treatment of thin gingival phenotype. Microneedling (MN) technique is a non-surgical procedure that is known as collagen induction therapy involving repetitive punctures on the skin. Over a petite period of time, it has expanded mass admiration and acceptance as it is a simple, inexpensive, and effective technique.PRF also induces higher fibroblast migration and expression of platelet-derived growth factor (PDGF), transforming growth factor B (TGF-B), and collagen-1 .Hyaluronic acid (HA), a naturally occurring polysaccharide, is considered an important component of the extracellular matrix in connective tissues of the human body.The unique biological and physiochemical properties of HA make it an interesting biomaterial for medical, cosmetic, and pharmaceutical applications.

In light of these factors, due to the positive effects of HA, MN and I-PRF on the biological potential, neoangiogenesis, neocollagenesis and wound-healing, the aim of this study is meant to compare the clinical efficacy of  micro-needling with  I-PRF and HA  in thin gingival phenotype.