Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 360
- 主要终点
- Chemical Pregnancy Rate
研究概览
简要总结
The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.
详细描述
In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome.
Little is known about the efficacy of this procedure in improving intrauterine insemination outcome.
Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18 - 38 years.
- •patent fallopian tunes.
- •mild male factor.
- •anovulation.
- •unexplained infertility.
排除标准
- •indications for ICSI.
- •evidence of pelvic inflammatory disease.
研究组 & 干预措施
no endometrial injury
Ovarian stimulation combined with intrauterine insemination.
干预措施: intrauterine insemination (Procedure)
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
干预措施: endometrial injury. (Procedure)
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
干预措施: intrauterine insemination (Procedure)
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
干预措施: ovarian stimulation (Drug)
no endometrial injury
Ovarian stimulation combined with intrauterine insemination.
干预措施: ovarian stimulation (Drug)
结局指标
主要结局
Chemical Pregnancy Rate
时间窗: two weeks after intrauterine insemination
Human chorionic gonadotrophin (b-hcg) detection in serum two weeks after intrauterine insemination.
Clinical Pregnancy Rate
时间窗: six weeks
Ultrasound detection of an intrauterine positive fetal heart pulsations
次要结局
未报告次要终点
研究者
Ahmed Mohamed Bahaa Eldin Ahmed
lesturer in Obstetrics and Gynecology.
Ain Shams Maternity Hospital