Prospective Physiopathology Study of the Links Between Mitochondrial Dynamics and Fatty Liver Disease During Obesity
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Association between nonalcoholic steato-hepatitis and mitochondria morphological markers
研究概览
简要总结
The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.
详细描述
The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis. The protocols involves a per-operative hepatic needle biopsy for mitochondria characterization and histological scoring of steatosis, inflammation, and fibrosis
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult men and women
- •affiliated to a social security
- •candidate for laparoscopic obesity surgery
排除标准
- •Excessive alcohol consumption:> 20 g / day (woman),> 30 g / day (male)
- •Chronic viral hepatitis B or C
- •Genetic hemochromatosis
- •Taking the following drugs for at least 3 months up to 6 months before the scheduled date of obesity surgery: systemic corticosteroids, amiodarone, methotrexate
- •Wilson's disease
- •autoimmune hepatitis
- •alpha 1-antitrypsin deficiency
- •abetalipoproteinemia
- •Contraindications to liver biopsy
研究组 & 干预措施
Experimental Group
the biopsies will be performed under laparoscopy and taken in the lower part of the right hepatic lobe
干预措施: liver biopsy (Other)
结局指标
主要结局
Association between nonalcoholic steato-hepatitis and mitochondria morphological markers
时间窗: Until 6 month
次要结局
未报告次要终点