NCT02186639已完成不适用
Exhaled Breath Analysis in Patients With COPD by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- COPD-specific mass spectrometric exhaled breath pattern
研究概览
简要总结
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
详细描述
This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC < 0.7) performed within the last 6 months
- •age between 18 and 80 years at study entry
- •healthy controls: normal spirometry
排除标准
- •COPD exacerbation within the last 6 weeks
- •any lung disease other than COPD
- •acute inflammatory disease (e.g. common cold) within the last 6 weeks
- •acute or chronic hepatic disease
- •renal failure or renal replacement therapy
结局指标
主要结局
COPD-specific mass spectrometric exhaled breath pattern
时间窗: baseline
次要结局
未报告次要终点
研究者
研究点 (1)
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