Effect of Intraoperative Dexmedetomidine infusion on Postopearative Cognitive Dysfunction and Recovery Quality in an Elderly Patient posted for Spine Surgery: a Randomized Prospective Double Blinded Study

Indraprastha Apollo Hospital New Delhi0 个研究点目标入组 60 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•Patients with American Society of Anesthesiologists (ASA) physical status I-III aged 60- 80 years old, undergoing elective lumbar spine surgery

•1.Patients age less than 60 years and more than 80 years old.
•2.Patients with a pre-operative or intraoperative ECG (electrocardiogram) that showed severe bradycardia (sinus rhythm, heart rate less than 50/ min) or conduction block
•3.Patients with associated renal, hepatic and respiratory dysfunction.
•4.Patients with history of central nervous system disease such as head injury, stroke, previous neurosurgery, behavioral disturbances or mental retardation.
•5.Patients with preoperative cognitive dysfunction (MMSE <24)
•6.Patients on Î²-blockers, cimetidine, digoxin, Î±2-agonists, anticonvulsants or psychotropic medications
•7.Patients with allergy to dexmedetomidine or another alpha-2 adrenergic receptor agonist

发起方

Indraprastha Apollo Hospital New Delhi