Identification of Novel Bioactive Compounds in Wheat Bran
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Human bioavailability of acetophenones from wheat bran cereals
研究概览
简要总结
There is a lot of evidence to suggest that eating a diet rich in cereals such as wheat bran are beneficial in protecting us from diseases such as heart disease, diabetes and cancer. It is still not clear exactly why this happens, but it is likely that the compounds which enter our bodies when we eat such products are responsible. In this study we plan to find out what these compounds are and where they are found. The investigators will do this by asking volunteers to eat a wheat-bran meal and then measuring the compounds that appear in blood, urine and stool samples over the next twenty-four hours. Once the investigators know how much and which compounds are present, we can then find out possible reasons why they are protective, for example by looking to see whether they are anti-inflammatory. We also plan to look at whether if having a diet which contains either a lot of wheat-bran products or very low amounts of these foods effects how they are absorbed by the body.
HYPOTHESIS: Wheat bran from ready-to-eat cereal has unique phytochemical profiles which are metabolized to compounds responsible for high cellular bioactivity imparting important health benefits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Volunteers will be healthy males or females and aged between 18 and 55 years who have a documented low (less than 1 portion per week) or high (more than or equal 5 portions per week) consumption of wheat bran and are able to give informed consent.
排除标准
- •are taking any medicines prescribed by their general practitioner
- •are taking drugs to lower high cholesterol levels or high blood pressure
- •regularly take analgesics, antipyretic or anti-inflammatories
- •regularly take nutritional supplements
- •have taken antibiotics in the last three months
- •have given a large blood donation in last three months
结局指标
主要结局
Human bioavailability of acetophenones from wheat bran cereals
时间窗: over 24h
The analysis of the acetophenones metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Short chain fatty acids profile after wheat bran consumption (acute)
时间窗: 24 h
Short chain fatty acids profile in faecal samples at 0h (baseline) and 24h after wheat bran consumption (40g and 120g).
Human bioavailability of phenylpropanoid dimers from wheat bran cereals
时间窗: over 24h
The analysis of the phenylpropanoid dimers metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Bioavailability of benzaldehydes from wheat bran
时间窗: over 24h
The analysis of the benzaldehydes metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Human bioavailability of benzoic acids and derivatives from wheat bran cereals
时间窗: over 24 h
The analysis of the benzoic acid and derivatives metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Human bioavailability of lignans from wheat bran cereals
时间窗: over 24 h
The analysis of the lignans metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Human bioavailability of cinnamic acids and derivatives from wheat bran cereals
时间窗: over 24h
The analysis of the cinnamic acids and derivatives metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Human bioavailability of phenyl propionic acids from wheat bran cereals
时间窗: over 24h
The analysis of the phenyl propionic acids metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h).
Short chain fatty acids profile after wheat bran consumption (chronic)
时间窗: 9 days
Short chain fatty acids profile in in faecal samples at day 0 (baseline), day 5 (during 7 days consumption of 40g wheat bran cereals/day) and day 10 (after 120g wheat bran cereals consumption on day 9).
次要结局
未报告次要终点