Effect of Thoracic Epidural Analgesia on Bowel Function Recovery in Major Upper Abdominal Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- gas out time
研究概览
简要总结
The investigators try to find whether thoracic epidural analgesia (TEA) shortens the first gas-out time compared to iv-PCA and promotes earlier discharge after major upper abdominal surgery.
详细描述
Postoperative ileus (POI) is a prolonged inhibition of coordinated bowel activity after surgery. Half of patients undergoing major abdominal surgery experience POI making it one of the limiting factors for early recovery.
The pathogenesis of POI is multifactorial, and includes neurogenic, inflammatory and pharmacological mechanisms. Thoracic epidural analgesia (TEA) can induce sympathetic block, attenuate inflammatory reaction and limit use of systemic opioids. In addition, sympatholysis induced by TEA can improve microcirculation of bowels and parasympathetic activation can increase gastrointestinal motility.
However, studies comparing TEA and iv-PCA on POI are rare in major upper abdominal surgeries. This study, therefore, compares TEA and iv-PCA in terms of bowel function recovery as a primary endpoint in major upper abdominal surgeries. Secondary endpoints are side effects and hospital stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists' (ASA) physical statusⅠ-Ⅲ
排除标准
- •ASA status of Ⅳ, or more
- •Body mass index 30 kg.m2-1 or more
- •Severe renal, hepatic, or neurologic diseases
- •Opioid or systemic analgesic preoperatively
研究组 & 干预措施
TEA
thoracic epidural analgesia group
干预措施: thoracic epidural analgesia (Procedure)
iv-PCA
intravenous patient controlled analgesia group
干预措施: iv-PCA (Drug)
结局指标
主要结局
gas out time
时间窗: from operation to post operative 10 days
次要结局
- voiding time(from operation to post operative 10 days)
- numeric rating scale for pain(from operation to post operative 3 days)
研究者
Hyun Joo Ahn
Associate professor
Samsung Medical Center