NCT02594345已完成不适用
In Vitro Study of the Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation in Healthy Volunteers' Blood
Johann Wolfgang Goethe University Hospital2 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2015年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- clotting time
研究概览
简要总结
This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.
详细描述
The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEM®) and FACS analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
排除标准
- •pregnancy
结局指标
主要结局
clotting time
时间窗: 2 months
measured by thromboelastometry (ROTEM® Analysis)
次要结局
- clot formation(1h after exposure)
- clot stability(1h after exposure)
- clot lysis(1h after exposure)
- CD62P(3h after exposure)
研究者
Dr Dania Fischer
Research associate
Johann Wolfgang Goethe University Hospital
研究点 (2)
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