COMPARISON OF NEBULIZED LIGNOCAINE AND NEBULIZED KETAMINE AS AN ADJUVANT TO GENERAL ANAESTHESIA IN ATTENUATING STRESS RESPONSE TO INTUBATION AND IN REDUCING THE INCIDENCE OF POSTOPERATIVE SORE THROAT
试验速览
- 阶段
- Phase 3 4
- 状态
- 已完成
- 发起方
- 入组人数
- 164
- 试验地点
- 1
- 主要终点
- To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
研究概览
简要总结
A randomized clinical trial to compare the efficacy of Lignocaine(3 mg/kg) nebulisation and Ketamine nebulisation(1 mg/kg) in reducing stress response to intubation and post operative sore throat in patients requiring General Anaesthesia with endotracheal intubation. Sample size was 162 (54 in each group).
From the study we concluded that nebulization with ketamine and lignocaine are equally effective in reducing hemodynamic stress response and post operative sore throat following endotracheal intubation. There was marked rise in hemodynamic parameters and incidence of postoperative sorethroat in control group (normal saline nebulisation).
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status 1 and 2 Elective surgeries Surgeries requiring General Anaesthesia with endotracheal intubation Surgeries in supine position.
排除标准
- •Surgeries lasting for more than 4 hours Known allergy to Lignocaine or Ketamine Recent history of cough or sore throat Nasal or oral surgeries Anticipated difficult airway Pregnancy Obesity, BMI>30 Uncontrolled hypertension.
结局指标
主要结局
To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
时间窗: To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
次要结局
- To compare the reduction in incidence of postoperative sore throat with use of Lignocaine and Ketamine nebulisation(24 hours after surgery)