Can continuous positive airway pressure treatment of patients with moderate obstructive sleep apnoea prevent sleep apnoea-related brain damage?

Dr. Carrie Innes0 个研究点目标入组 45 人开始时间: 2014年11月17日最近更新: 2021年1月5日

适应症

试验速览

暂无简介。

•All participants:
•Be at least 18 yrs but no older than 80 yrs.
•Normal time to bed between the hours of 0900 pm and 1200 am.
•Normal time in bed of 7 to 9 hours.
•Have a basic ability in English (verbal and written).
•Participants with moderate OSA:
•Be diagnosed with moderate OSA (15 - 29 OSA-related events per hour during Level 2 Sleep Study.
•Participants without OSA:
•Have <10 OSA-related events per hour during Level 2 Sleep Study.

•Currently receiving or previously received OSA treatment.
•A history of physiological, psychiatric, or neurological disorders that could affect or is affecting sleep behaviour, fatigue, cerebral perfusion or brain structure (e.g. chronic obstructive pulmonary disease, congestive heart disease, diabetes, heart failure, hypertension > 150/90, migraine, myocardial infarction, stroke, previous brain surgery, stroke, traumatic brain injury, etc., but not mild depression).
•Currently taking any medication that could impact on cerebral perfusion (e.g., ACE inhibitors, nitrates …).
•Not willing or unable to give consent.
•Not willing or unable to remove metal that could either be harmful to the participant during a MRI or could likely create MRI artefacts that negatively affect the quality of the scan.
•Based on current Sleep Unit criteria, not have any reason for urgent treatment.

发起方

Dr. Carrie Innes