Comparison of Effectiveness of Subgingivally Delivered Boric acid gel and Curcumin gel as an adjunct to Mechanotherapy in Chronic Periodontitis: A clinical study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Probing pocket depth reduction
研究概览
简要总结
Periodontitis,a chronic inflammatory disease, is induced by bacterial biofilms that initiatehost response in gingival connective tissue. It is considered an infection because there is abacterial etiology and an immune response. Sub gingivalenvironment is Ideal for pathogenic bacteria andSub gingival microorganisms are the principleetiologic factor in the development of periodontitis. Conventionaltherapy (e.g., scaling and root planing [SRP] and ultrasonic debridement)without adjunctive chemotherapy is often sufficient to suppress bacterialpathogens, thereby attaining periodontal health. Local delivery of antimicrobial agents in Periodonticsimplies antimicrobial therapy placed directly in the sub gingival region. Borinic acid are quinoline esters, arecently-identified class of new antibacterial compounds that contains boron. Itplays a role in inflammatory and immune response regulation. Italso plays a vital role in osteogenesis and the maintenance of bones. Curcumin, the primary active constituent of turmeric exhibits anti-inflammatory, anti-oxidant, anticarcinogenic, antiviral, and antimicrobial activities. Therefore, the present study will be undertaken to evaluate and compare the effectiveness of boric acid gel and curcumin gel as an adjunct to scaling and root planing in patients with chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients motivated to have the therapy and willing to complete the follow-up.
- •Patients with a minimum of 20 teeth.
- •Subjects who readily give informed consent for the study.
- •Systemically healthy subjects, with deep pockets.
- •Patients with no history of periodontal therapy ij the preceding 6 months or under any antibiotic therapy.
排除标准
- •Patients on systemic boron therapy, those with a known or suspected allergy to boron supplementation or curcumin.
- •Patients who have undergone periodontal therapy in the last 6 months.
- •Patients who were taking and had consumed vitamin supplements, anti-inflammatory agents, or statins in the previous 3 months.
- •Patients with any systemic disorder affecting periodontal health.
- •Patients with infectious conditions other than periodontitis.
- •Regular users of mouthwashes.
- •Chronic alcoholics
- •Those with aggressive periodontitis.
- •Immunocompromised and systemically unhealthy patients.
- •Pregnant or lactating females.
结局指标
主要结局
Probing pocket depth reduction
时间窗: baseline, post-operatively 3 months and 6 months
次要结局
- Clinical attachment level gain(baseline, post-operatively 3 months and 6 months)