Comparable Reductions in Health Biomarkers Following High-Intensity Interval or Concurrent Training in Obese Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Serum Total Antioxidant Capacity (TAC)
研究概览
简要总结
Introduction: Menopause is associated with body composition change, an increase in the cardio-metabolic risk factor for oxidative stress. Nevertheless, it has been suggested that regular physical training is an effective non-pharmacological intervention to reduce oxidative stress and cardio-metabolic disorders in menopausal individuals. Therefore, the present study was conducted to compare the effects of twelve weeks of high-intensity interval training (HIIT) and concurrent (Conc) and on body composition, cardio-metabolic indices and oxidative stress in sedentary obese postmenopausal women.
Materials and methods: Forty-five menopausal obese women voluntarily participated and were randomly assigned into three groups: a) HIIT (6-12×60s of high intensity training (85-95% HRMax) and then running for 60 seconds with low intensity (55-60% HRMax)), b) concurrent endurance (performed on training with 55-75% HRMax) and strength training (including two sets in eight exercise stations with 55-75% 1RM)) and c) control group. Training programs were done for twelve weeks, 3 times per week. Body composition, cardio-metabolic indices and oxidative stress markers were measured before and after twelve weeks of exercise training program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women with at least 12 months of amenorrhea.
- •Physical abilities with the capacity to exercise safely as determined by a medical evaluation.
- •Women in a sedentary state, defined as performing <150 minutes of moderate to vigorous physical activity per week during the previous year.
- •BMI >25 and ≤40 kg/ m2
排除标准
- •hormone replacement therapy
- •diagnosed cardiovascular, renal, or hepatic disease, uncontrolled hypertension, or any musculoskeletal limitation precluding exercise participation
结局指标
主要结局
Serum Total Antioxidant Capacity (TAC)
时间窗: first day of study and after 80 days of exercise training program (end of study)
Serum Total Antioxidant Capacity (TAC) measures the overall ability of antioxidants in your blood (serum) to neutralize harmful free radicals, reflecting your body's defense against oxidative stress, a key factor in aging and diseases
Concentration Malondialdehyde (MDA) (nmol/mL)
时间窗: first day of study and after 80 days of exercise training program (end of study)
Malondialdehyde (MDA) is a highly reactive compound and a key biomarker for oxidative stress, formed primarily from the breakdown (peroxidation) of polyunsaturated fatty acids in cell membranes, indicating cellular damage
Serum Total Antioxidant Capacity (TAC)
时间窗: first day of study and after 80 days of exercise training program (end of study)
Serum Total Antioxidant Capacity (TAC) measures the overall ability of antioxidants in your blood (serum) to neutralize harmful free radicals, reflecting your body's defense against oxidative stress, a key factor in aging and diseases
Concentration Monocyte Chemoattractant Protein-1 (MCP-1) (pg/mL)
时间窗: first day of study and after 80 days of exercise training program (end of study)
Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a vital CC chemokine that acts as a powerful signal, attracting monocytes, macrophages, and T cells to sites of inflammation, infection, and tissue injury in the body, playing a key role in innate immunity and various inflammatory diseases
次要结局
- Serum insulin(first day of study and after 80 days of exercise training program (end of study))
- Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)(first day of study and after 80 days of exercise training program (end of study))
- Body Mass Index(first day of study and after 80 days of exercise training program (end of study))
- Waist circumference (WC)(first day of study and after 80 days of exercise training program (end of study))
- hip circumference (HC)(first day of study and after 80 days of exercise training program (end of study))
- waist-hip ratio (WHR)(first day of study and after 80 days of exercise training program (end of study))
- total cholesterol (TC)(first day of study and after 80 days of exercise training program (end of study))
- Atherogenic Index of Plasma (AIP)(first day of study and after 80 days of exercise training program (end of study))
- Body Mass Index(first day of study and after 80 days of exercise training program (end of study))
- hip circumference (HC)(first day of study and after 80 days of exercise training program (end of study))
- % Body Fat(first day of study and after 80 days of exercise training program (end of study))
- Waist circumference (WC)(first day of study and after 80 days of exercise training program (end of study))
- waist-hip ratio (WHR)(first day of study and after 80 days of exercise training program (end of study))
- total cholesterol (TC)(first day of study and after 80 days of exercise training program (end of study))
- Concentration Triglycerides (TG) (mg/dl)(first day of study and after 80 days of exercise training program (end of study))
- Concentration High-Density Lipoprotein Cholesterol (HDL-C) (mg/dl)(first day of study and after 80 days of exercise training program (end of study))
- Concentration Low-Density Lipoprotein Cholesterol (LDL-C) (mg/dl)(first day of study and after 80 days of exercise training program (end of study))
- Atherogenic Index of Plasma (AIP)(first day of study and after 80 days of exercise training program (end of study))
- Serum insulin(first day of study and after 80 days of exercise training program (end of study))
- Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)(first day of study and after 80 days of exercise training program (end of study))
研究者
Diego Fernández Lázaro
Professor Doctor
University of Valladolid