Prospective, Multicenter, Clinical and Biological Database Set-up in Colon Cancer and Colic Tumors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 600
- 试验地点
- 4
- 主要终点
- Number of biological risk factors for colorectal cancer
研究概览
简要总结
Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.
详细描述
As the second leading cause of cancer-related death in France, colorectal cancer is a major public health problem. Each year, 37 000 cases are newly diagnosed in France and 17 000 patients die of the disease.
Colorectal cancer is due to molecular and genetic damages involved in all tumorigenesis steps, transition from healthy tissue to adenoma and finally to invasive carcinoma stage. The investigators hope that a to better understand tumor invasion and metastatic scattering processes will allow therapeutic innovation and the emergence of new biomarkers.
However, the study of early tumorigenesis phases as well as advanced stages of the disease is currently limited due to a lack of tissue samples.
In this context, the Montpellier Cancer Institute (ICM) decided to initiate a biological collection dedicated to the tissular and blood samples of patients with colorectal cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient undergoing colon cancer surgery (stage I, II, III and IV)
- •Patient operated for liver or lung or peritoneal carcinomatosis metastases originating from colon cancer
- •Patient operated for pre-neoplastic lesion (adenomatous polyp /villous adenoma polyp),
- •Patient with familial polyposis eligible for colectomy
- •Age > 18 years
- •Signed informed consent
排除标准
- •Patient not affiliated to Social Protection system
- •Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons
- •Patient under guardianship
- •Minor patient
结局指标
主要结局
Number of biological risk factors for colorectal cancer
时间窗: Until the study completion : 6 years
Number of clinical risk factors for colorectal cancer
时间窗: Until the study completion : 6 years
次要结局
未报告次要终点