NCT01074918撤回1 期
Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients; Role of Natriuresis
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Blood Pressure
研究概览
简要总结
The goal of this study is to compare the effects of Potassium Magnesium Citrate to Potassium Chloride on blood pressure among patients with pre-hypertension or mild hypertension. We will also test whether Potassium Magnesium Citrate increases excretion of large amounts of sodium in the urine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 21 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age greater than 21 years
- •BMI > 18.5 kg/m2 and < 40 kg/m2
- •Prehypertension and mild hypertension: BP systolic 120-159 mmHg, diastolic 80-95 mmHg
- •Must agree to limit lifestyle changes including: 1) embarking on a new exercise or weight reduction program 2) altering alcohol intake during the trial.
排除标准
- •Taking blood pressure lowering medication
- •Diabetes mellitus
- •Renal disease
- •Active cardiac disease
- •Active liver disease
- •Chronic diarrhea
- •Chronic NSAID use
- •Active or suspected drug use
- •Uncontrolled psychiatric disease
- •HIV infection
- •Missed more than 20% of clinic visits in the last yr
- •Prescription of diuretics for any reason
- •A patient taking nutritional supplements including multivitamins that is unwilling to discontinue them,\
- •Consumption of greater than 14 alcoholic beverages per week
研究组 & 干预措施
Potassium Magnesium Citrate
Experimental
干预措施: Potassium, Magnesium, Citrate (Drug)
Potassium Chloride
Active Comparator
干预措施: Potassium Chloride (Drug)
结局指标
主要结局
Blood Pressure
时间窗: 8 weeks
We have estimated to detect a 4 mmHg difference, with a standard deviation estimated at 8 mmHg.
次要结局
未报告次要终点
研究者
Orson Moe
Professor of Internal Medicine
University of Texas Southwestern Medical Center
研究点 (2)
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