Cardiopulmonary Effects of Secondhand Smoke Exposure on Flight Attendants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 592
- 试验地点
- 1
- 主要终点
- Characterize the long-term effects of SHS on lung and cardiovascular function in pre-ban flight attendants
研究概览
简要总结
This is a study on a population of flight attendants who were exposed to occupational secondhand tobacco smoke (SHS). This research will examine associations between flight attendant SHS exposure and development of respiratory illnesses, reproductive problems, and cardiovascular diseases.
详细描述
The main hypothesis of this study is that exposure to the secondhand tobacco smoke (SHS) in the confined workspace of commercial aircraft prior to the ban of cigarette smoking is responsible for long-term damage on the health of nonsmoking flight attendants. We will compare the data collected from our pre-ban flight attendant participants to age-matched, nonsmoking controls from the NHANES (National Health and Nutrition Examination Survey) database. The results of our study should permit us to determine if SHS exposure is the cause of long-term increased cardiovascular morbidity and risk, as well as increased susceptibility to respiratory illnesses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Never smoker flight attendants who began working for airlines before the smoking ban on aircrafts went into effect. Never smoker is defined as those with history of tobacco use of less than 100 cigarettes in their lifetime.
- •SHS exposure for at least 1 year while working with the airlines.
排除标准
- •Less than 1 year of occupational exposure to SHS
- •Smoking more than 100 cigarettes over a lifetime
结局指标
主要结局
Characterize the long-term effects of SHS on lung and cardiovascular function in pre-ban flight attendants
时间窗: 25 minutes
A spirometry test is performed by the Clinical Research Coordinator to establish the lung function of the flight attendant participant and medical assistants from the cardiovascular care clinic administer a 12-lead non-invasive electrocardiogram.
次要结局
- Characterize the biomarkers of SHS exposure(10 minutes)
- Characterize the long term effects of prolonged flight time and SHS on reproductive health(10 minutes)
- Clinical Examination(30 min)