Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- success of sedation
研究概览
简要总结
This study evaluate the effect of adding dexmedetomidine intravenous infusion to propofol intravenous infusion during sedation for drug induced sleep endoscopy. Twenty five patients will receive propofol only while the other twenty five will receive propofol and dexmedetomidine.
详细描述
Propofol is a commonly used intravenous anesthetic drug used for procedural sedation. Dexmedetomidine is an alpha 2 adrenergic receptor agonist which has a sedative and analgesic effects.In the current study the success of the sedation during drug induced sleep endoscopy will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age more than 18 years
- •patients with obstructive sleep apnea
- •ASA 1and2
排除标准
- •patient refusal
- •age less than 18 years
- •morbid obesity
- •known or suspected allergy to the studied drugs
研究组 & 干预措施
propofol
patients will receive only propofol intravenous infusion for sedation
干预措施: Propofol (Drug)
propofol-dex.
patients will receive dexmedetomidine in addition to propofol intravenous infusion for sedation
干预措施: Propofol (Drug)
propofol-dex.
patients will receive dexmedetomidine in addition to propofol intravenous infusion for sedation
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
success of sedation
时间窗: the duration of the procedure under sedation is usually about 20 minutes
to complete the procedure with diagnosis of site and degree of obstruction
次要结局
- time until sufficient sedation(about 5-10 minutes from start of sedation)
研究者
Essam Fathi
assistent professor
Zagazig University