Quantifying Microbial Keratitis to Predict Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 2
- 主要终点
- Visual Acuity
研究概览
简要总结
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm stromal infiltrate compared with participants with other forms of keratitis.
详细描述
The primary objective of this study is to determine associations between participant features (clinical and morphologic) and best corrected visual acuity at Day 90. Imaging, focused on slit lamp photography and supplemented by other imaging markers will be collected for review. A medical record review at one year following participants initial visit will record any corneal procedure and visual acuity testing that occurred during this window. Participants will complete demographic, clinical, and standardized health surveys.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cases- microbial keratitis (bacterial or fungal) with presence of clinically significant ≥2mm stromal infiltrate
- •Controls- Inflammatory, viral, Acanthamoeba, or other keratitis
排除标准
- •Pregnancy
- •Prior incisional corneal surgery
- •No light perception vision
- •Corneal perforation or impending perforation
- •Inpatient status
- •Institutional status
- •Cognitively impaired
结局指标
主要结局
Visual Acuity
时间窗: 90 day follow up
Visual Acuity
次要结局
未报告次要终点
研究者
Maria Woodward
Assistant Professor
University of Michigan