Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- estimate the change in levels of Fetuin A and MMP7 in serum at baseline and 3 months post SRP
研究概览
简要总结
The present clinico-biochemical study was carried out to estimate the levels of Fetuin A and MMP7 in serum of systemically healthy subjects in periodontal health and disease and to evaluate the impact of periodontal interventional therapy (scaling and root planing) on the same.
详细描述
Sixty sex-matched subjects (30 males and 30 females) belonging to a common age group (30-39 yrs) were enrolled for the study to eliminate bias from confounding factors. They were divided into three groups consisting of 20 subjects in each group based on the clinical and radiological parameters; Periodontally healthy (Group I), Chronic gingivitis (Group II) and chronic periodontitis ( Group IIIa) from whom serum samples were collected. The Group IIIb further comprised of the subjects from Group IIIa, who had received non-surgical periodontal therapy (scaling and root planing). Serum samples were collected at baseline and at 12 weeks post therapy. Fetuin A and MMP-7 concentration was determined from serum samples of patients using ELISA. The results of our study depicted that Fetuin A concentration negatively correlates, whereas, MMP7 positively correlates with the extent of periodontal inflammation. Further, Periodontal therapy demonstrated a significant increase in serum Fetuin A and decrease in MMP 7 levels establishing the influence of periodontal therapy in stabilizing their levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age group of 30-39 years.
- •Systemically healthy subjects.
- •Patient who are co-operative and able to attend follow up.
- •Patient who have not received any periodontal treatment within the past six months of baseline examination.
- •Dentition with at least 20 functional teeth.
排除标准
- •Medically compromised patients (history of diabetes mellitus, liver diseases, cardiovascular disease, kidney diseases, rheumatoid arthritis, bone diseases pulmonary disease, viral and fungal infections).
- •Patients with calcification disorders (chronic kidney disease with vascular calcification, hyperparathyroidism, excessive intake of vitamin D, valvular calcific aortic stenosis
- •Aggressive periodontitis.
- •Bleeding disorders
- •Gross oral pathology and suppuration
- •Patients who had received antibiotic therapy and anti inflammatory within the last six months.
- •Anomalies of the immune system.
- •Pregnancy and lactation.
结局指标
主要结局
estimate the change in levels of Fetuin A and MMP7 in serum at baseline and 3 months post SRP
时间窗: Serum collection at baseline and 3 months
Serum was collected at baseline and 3 months and subjected to ELISA
次要结局
- Modified Gingival index (GI)(At baseline and 3 months)
- Relative Attachment level (RAL)(At baseline and 3 months)
- Probing Depth (PD)(At baseline and 3 months)
- Bleeding on Probing (BOP%)(At baseline and 3 months)
- Plaque index (PI)(At baseline and 3 months)