NCT00966199Unknown4 期
Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Cerebral blood flow
研究概览
简要总结
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >= 70 years
- •Systolic office blood pressure >= 160 mmHg
- •Systolic home blood pressure >= 155 mmHg
排除标准
- •Diabetes Mellitus
- •Atrial fibrillation
- •Renal failure requiring dialysis
- •Life expectancy of less than 1 year
- •Disabling stroke
- •Contraindication for MRI or anti-hypertensive medication
- •Systolic blood pressure > 220 mmHg
研究组 & 干预措施
Hypertensive elderly
Experimental
community dwelling hypertensive elderly from general practices
干预措施: anti-hypertensive medication (Drug)
结局指标
主要结局
Cerebral blood flow
时间窗: T1, 8-12 weeks of treatment, T2
次要结局
- Cognitive functioning assessed by neuropsychological testing(T1, 8-12 weeks of treatment, T2-3)
研究者
研究点 (1)
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