NCT02781857已完成不适用
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS) in Patients With Lung Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 309
- 试验地点
- 2
- 主要终点
- Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry
研究概览
简要总结
To answer the question whether a disease specific profile of breath in patients with lung cancer can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed lung cancer based on cytological or histological analysis.
- •Group A: any type of lung cancer eligible for surgical resection (up to TNM stage IIIa).
- •Group B: any type of lung cancer (small-cell carcinoma, non-small-cell carcinoma) not amenable for surgical resection.
- •Group C: matched controls.
- •Age between 18 and 85 years at study entry
排除标准
- •Another 'active' secondary malignant disease (e.g. breast cancer, colon carcinoma) in group A and B, presence of any active malignant disease in group C (based on personal information).
- •Acute inflammatory disease (e.g. common cold) within the last 4 weeks.
- •Any other acute lung disease which affects breath measurements
- •Acute or chronic hepatic disease.
- •Renal failure or renal replacement therapy.
结局指标
主要结局
Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry
时间窗: 1 day, single measurement
The primary outcome will be the lung cancer specific mass spectrometric profile of VOCs of exhaled breath analysis (markers of lung cancer in exhaled breath).
次要结局
- Group A: Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry before and after lung cancer surgery(Group A: 2 measurements on 2 different days; Day 1: 1. measurement (before surgery), Day 2: (6-12 weeks after surgery): 2. measurement)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Breath Analysis in Lung FibrosisIdiopathic Lung FibrosisIdiopathic Pulmonary FibrosisNCT02437448University of Zurich31
已完成
不适用
Breath Analysis in AsthmaAsthmaExhaled BreathMass SpectrometryNCT02450461University of Zurich60
已完成
不适用
Breath Analysis in Healthy ControlsExhaled BreathMass SpectrometryHealthy SubjectsNCT02595632University of Zurich183
招募中
不适用
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and AdolescentsRespiratory DiseasesNeurological DisordersType 1 DiabetesNCT04461821University Children's Hospital Basel3,600
招募中
不适用
Exhaled Breath Analysis in Human SubjectsExhaled Breath Pattern After Medication Intake, in OSA Patients, or Other Pulmonary DiseasesNCT05456009University of Zurich1,500