Atrial and Ventricular Wall Stress, Effects of Breathing and Airway Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver
研究概览
简要总结
Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.
详细描述
With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adults
排除标准
- •known heart or lung disease
研究组 & 干预措施
Single arm, breathing manuevers
All subjects perform/undergo Valsalva, Muller, CPAP, hand grip, and passive leg raise, with ultrasound examination of heart recorded before and during the manoeuvre.
干预措施: Simple breathing manuevers during brief echocardiographic imaging (Other)
结局指标
主要结局
Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver
时间窗: 30 seconds, i.e. control measurement and then measurement during breathing manoeuver observed from same breathing/measurement sequence
Echocardiographic measure, comparing control measurement to measurement during breathing manoeuver
次要结局
未报告次要终点