TCTR20220214005Enrolling By Invitation1 期
Effects of colchicine on renal fibrosis marker in patients with chronic kidney disease: A randomized controlled trial
/A0 个研究点目标入组 40 人开始时间: 2022年2月14日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 85 Years（—）
- 性别
- All
入选标准
- •1. Adult patients, age between 18 to 85 years old
- •2. Chronic kidney disease stage 3 and 4, defined by KDIGO criteria which eGFR by creatinine-based Thai GFR equation is 15-59 ml per minute per 1.73 m2 of body surface area.
排除标准
- •1) acute kidney injury within 1 month before randomization
- •2) colchicine exposure within 3 month before randomization
- •3) kidney transplant patients
- •4) pre-existing or plan for immunosuppressive therapy
- •5) woman with pregnancy, lactation or unwilling to take contraception methods
- •6) cirrhosis or active hepatitis defined by elevated serum AST and/or ALT twice the upper limit
- •7) chronic diarrhea
- •8) neuromuscular disease
- •9) hematologic disease or abnormal complete blood count, any of the following; hemoglobin < 10 g/dL, white blood count <3,000 x 109/L or Platelet <100,000 x 109/L
- •10) active malignancy
- •11) pre-existing use of strong CYP3A4 or P-glycoprotein inhibitors medication
- •12) colchicine allergy
- •13) active COVID-19 infection before 2 weeks before randomization.
研究者
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