A Study of the Effect of Different Antihypertensive Drugs on the Disease Progression of Aortic Dissection/Aneurysm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 704
- 主要终点
- Aortic diameter
研究概览
简要总结
The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is:
Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.
详细描述
This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses.
This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aortic diseases' patients underwent aortic surgery who require antihypertensive medication.
排除标准
- •Patients with active vasculitis;
- •Patients allergic to contrast agent
- •Patients with aorta variation
研究组 & 干预措施
CCB group
Patients' postoperative antihypertensive includes CCB (Calcium Calcium Entry Blockers)
干预措施: CCB use (Drug)
non-CCB group
Patients' postoperative antihypertensive does not include CCB
干预措施: non-CCB use (Drug)
结局指标
主要结局
Aortic diameter
时间窗: Through the study completion, on an average of 3 years
The maximum diameter of the aorta measured by computed tomography angiography
次要结局
- Number of Participants with adverse aortic event(Through the study completion, on an average of 3 years)
研究者
Zhang Tingting
Professor
Eighth Affiliated Hospital, Sun Yat-sen University