Oxytocin Effects on Self and Other Processing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups
研究概览
简要总结
To determine whether the neuropeptide oxytocin (OXT) influences self-processing by investigating whether it increases the endowment effect in relation to both self and others.
详细描述
In a double-blind, between- subject placebo (PLC) controlled design, investigator aimed to measure the effect of intranasal OXT on the endowment effect. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), self-esteem scale (SES). Subjects were asked to decide whether to buy or sell their own or others' (their mothers'/ fathers'/ classmate'/ strangers') possessions at various prices. Indifference point and brain activation were inluded into analysis as dependent variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 27 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
研究组 & 干预措施
Oxytocin
Oxytoxin nasal spray
干预措施: Oxytocin (Drug)
Placebo
Placebo nasal spray
干预措施: Placebo (Drug)
结局指标
主要结局
Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups
时间窗: 1 hour
Indifference point is the gap between willingness to accept and willingness to pay ;focus on the specfic brain region relasted to self-processing, such as medial prefrontal cortex, precuneus, posterior cingulate cortex, ventral striatum.
次要结局
未报告次要终点