Effects of Anesthetics on Inflammatory Markers in Patients Undergoing Abdominal Surgeries.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 81
- 试验地点
- 1
- 主要终点
- Visual analogue score
研究概览
简要总结
undertake confidently both open and laparoscopic cholecystectomy. Major types of body injuries surgical or accidental; evoke a temporary, yet predictable systemic inflammatory response caused by hormonal, immunological and metabolic mediators. This inflammatory response is essential for tissue repair and has evolved to maximize the organisms' healing potential. In healthy individuals the inflammatory response to major surgery is well balanced consisting of pro- and anti-inflammatory mediators. The severity of injury, the occurrence of surgical complications and its accompanying level of stress may hinder the balance of the inflammatory response6.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients aging 18 - 55 years old
- •Patients scheduled for abdominal surgeries
- •Patients with American Society of Anesthesiologists (ASA) I, II physical status
排除标准
- •Patients' refusal.
- •Critically ill patients.
- •Patients who have contraindications to regional anesthesia.
研究组 & 干预措施
G-M
Received classic general Anesthesia, intrathecal (Bupivacaine 15 mg, morphine 4 microgram/kg) plus saline infusion intraoperative and postoperative.
干预措施: Morphine Sulfate (Drug)
G-ML
Received classic general Anesthesia, intrathecal morphine in a dose of 4 microgram/kg, and intravenous lidocaine in a loading dose of 1.5 mg/kg, then 2 mg/min with the saline infusion over the time of the operation and the next 4 hours postoperative.
干预措施: morphine+lidocaine (Drug)
G-0
Received General Anesthesia and Spinal anesthesia as previously described with saline infusion in the same design as in the previous two groups.
干预措施: Saline (Drug)
结局指标
主要结局
Visual analogue score
时间窗: 24 hours
a scale to measure pain intensity graded from 0 = no pain to 10 = worst pain
次要结局
未报告次要终点
研究者
Esam Hamed
clinical professor
Assiut University