Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 153
- 试验地点
- 1
- 主要终点
- natural killer cell activity
研究概览
简要总结
Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.
The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
详细描述
The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.
- immediate before anesthesia induction
- postoperative 1 hours
- postoperative 24 hours
Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient who was planned to undergo colon cancer surgery.
排除标准
- •age < 20 years old
- •history of hypersensitivity reaction in propofol or sevoflurane
- •history of previous cancer
- •patient with ongoing inflammation
研究组 & 干预措施
propofol group
The patient who anesthetized by using propofol.
干预措施: propofol group (Drug)
sevoflurane group
The patient who anesthetized by using propofol.
干预措施: sevoflurane group (Drug)
结局指标
主要结局
natural killer cell activity
时间窗: preoperative time. postoperative 1 hours and 24 hours
change of percentage of natural killer cell (scores range from 0 to 100)
次要结局
- helper T cell activity(preoperative time. postoperative 1 hours and 24 hours)
研究者
Seong-Hyop Kim
Associate Professor
Konkuk University Medical Center