Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Breast Cancer

Not Applicable

Completed

• Conditions: Breast Cancer
• Interventions: Drug: propofol group; Drug: sevoflurane group

• Registration Number: NCT02567929
• Lead Sponsor: Konkuk University Medical Center

Brief Summary

Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.

The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Detailed Description

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.

1. immediate before anesthesia induction

2. postoperative 1 hours

3. postoperative 24 hours

Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay

Study Timeline

• Study First Submitted: 2015-09-02
• Study First Submitted QC: 2015-10-01
• Study First Posted: 2015-10-05
• Study Start: 2016-03
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-30
• Last Update Posted: 2018-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 218

Inclusion Criteria

• patient who was planned to undergo colon cancer surgery.

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Exclusion Criteria

• age < 20 years old
• history of hypersensitivity reaction in propofol or sevoflurane
• history of previous cancer
• patient with ongoing inflammation

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
propofol group	propofol group	The patient who anesthetized by using propofol.
sevoflurane group	sevoflurane group	The patient who anesthetized by using propofol

Primary Outcome Measures

Name	Time	Method
CD39 and CD73 on circulating regualtory T cells	preoperative time. postoperative 1 hours and 24 hours	change of percentage of CD39 and CD73 (scores range from 0 to 100)

Secondary Outcome Measures

Name	Time	Method
Circulating natural killer cells	preoperative time. postoperative 1 hours and 24 hours	change of percentage of circulating natural killer cell (scores range from 0 to 100)

Trial Locations

Locations (1)

Konkuk University Medical Center; 🇰🇷 Seoul, Korea, Republic of