Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Breast Cancer
Overview
- Phase
- Not Applicable
- Intervention
- propofol group
- Conditions
- Breast Cancer
- Sponsor
- Konkuk University Medical Center
- Enrollment
- 218
- Locations
- 1
- Primary Endpoint
- CD39 and CD73 on circulating regualtory T cells
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.
The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
Detailed Description
The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order. 1. immediate before anesthesia induction 2. postoperative 1 hours 3. postoperative 24 hours Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay
Investigators
Seong-Hyop Kim
Associate Professor
Konkuk University Medical Center
Eligibility Criteria
Inclusion Criteria
- •patient who was planned to undergo colon cancer surgery.
Exclusion Criteria
- •age \< 20 years old
- •history of hypersensitivity reaction in propofol or sevoflurane
- •history of previous cancer
- •patient with ongoing inflammation
Arms & Interventions
propofol group
The patient who anesthetized by using propofol.
Intervention: propofol group
sevoflurane group
The patient who anesthetized by using propofol
Intervention: sevoflurane group
Outcomes
Primary Outcomes
CD39 and CD73 on circulating regualtory T cells
Time Frame: preoperative time. postoperative 1 hours and 24 hours
change of percentage of CD39 and CD73 (scores range from 0 to 100)
Secondary Outcomes
- Circulating natural killer cells(preoperative time. postoperative 1 hours and 24 hours)