Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The occurrence of cough during anesthetic emergence
研究概览
简要总结
In patients undergoing hypophysectomy through transsphenoidal approach, preventing cough during anesthetic emergence is important to avoid hemorrhage and cerebrospinal fluid leakage. Previous reports demonstrated that administration of remifentanil during anesthetic emergence could reduce the incidence and severity of cough during anesthetic emergence. Therefore, the objective of this study is to determine EC95 of remifentanil for preventing cough during anesthetic emergence in patients undergoing hypophysectomy with transsphenoidal approach.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled to undergo hypophysectomy with transsphenoidal approach
- •American Society of Anesthesiologists physical status I or II
- •more than 20 years old
排除标准
- •acute or chronic respiratory disease
- •uncontrolled hypertension
- •taking sedatives or anti-tussive
- •gastro-esophageal reflux
- •pregnant or breast feeding
- •patients who cannot understand statements for subjects or this study itself
研究组 & 干预措施
group 1
administration of remifentanil with target-controlled infusion (TCI) system at a given concentration during anesthetic emergence
干预措施: Administration of remifentanil with TCI system (Drug)
结局指标
主要结局
The occurrence of cough during anesthetic emergence
时间窗: 5 min after extubation
At a given effect-site concentration of remifentanil, if cough does not occur during anesthetic emergence, it would be considered as a success. On the other hand, if cough occurs during anesthetic emergence, it would be considered as a failure.
次要结局
未报告次要终点