Changing How the Brain Responds When Making Decisions: Translating Neuroscience to Population Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Brain Activation in Self-Regulation Brain Regions
研究概览
简要总结
The current study will examine the relationship between brain responses and a guided imagery exercise in overweight and obese individuals. Results of this work are highly relevant to public health because they employ neuroimaging methods to understand food decision-making. Findings from this study will inform health decision making and holds great potential for future translation across multiple health behaviors and scalable interventions to impact population health
详细描述
Negative health behaviors (e.g. overeating, smoking) are associated with increased negative health outcomes. Engaging in healthy behaviors is not always rewarding (e.g. carrot vs. cake). Neural models of healthy behaviors focus on the balance between reward and regulation brain regions. The current pilot application examines the engagement of these regions during the evaluation of food and nonfood cues before and after a guided imagery exercise targeting positive associations with food and regulation.
The long-term goal is to understand the interaction between positive associations with healthy foods and thinking about future rewards may influence healthy decision-making. The objective of the current study is to empirically test the combined effects of positive affect and positive episodic future thinking on brain activation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index 25 to 55 kg/m2
- •right-handed
- •not currently dieting or attempting to lose weight.
排除标准
- •serious medical illness unsuitable for the magnetic resonance imaging scanner based on best clinical judgment
- •any neurologic or current psychiatric diagnosis
- •currently taking anti-seizure medication
- •history of concussion
- •left-handedness
- •risk for hazard due to magnetic fields such as metal in the body surgically or accidentally
- •pregnancy
结局指标
主要结局
Brain Activation in Self-Regulation Brain Regions
时间窗: 1 hour
Functional Magnetic Resonance Imaging will measure brain activation changes in self-regulation brain regions including the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex when participants view healthy compared to unhealthy food images before and after the guided imagery exercise
Brain Activation in Reward Brain Regions
时间窗: 1 hour
Functional Magnetic Resonance Imaging will measure brain activation changes in reward brain regions including the ventromedial prefrontal cortex and striatum when participants view healthy compared to unhealthy food images before and after the guided imagery exercise
次要结局
- Food Choice(1 hour)
- Food Demand(1 hour)