Understanding the Influence of Diaphragm Structure and Function on the Control of Breathing During Exercise in Childhood Cancer Survivors (2373GCCC)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Adherence to treatment protocol
研究概览
简要总结
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.
详细描述
During the first study visit, participants will undergo a series of pulmonary function and muscle performance tests followed by treadmill walking trials at different speeds with concurrent expired gas analysis via a face mask. The participants will then perform a training program for the breathing muscles at home for 6 weeks. The research team will follow up each week via telehealth visits to support training. After the 6-week training program, participants will return in-person for a follow-up visit and will undergo the same series of assessments as the first visit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Completed medical treatment (chemotherapy, chemotherapy/surgery, chemotherapy/radiation or any combination of cancer treatment) for any type of cancer, except for cancer of the central nervous system, at least 1 year ago
排除标准
- •History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis of cancer
- •Recent injury or condition (less than 6 months ago) that precludes strength testing or walking
- •Dyspnea with minimal activity (4 on the modified Medical Research Council Dyspnea Scale)
研究组 & 干预措施
Inspiratory Muscle Training (IMT)
Participants will be asked to perform inspiratory muscle training (breathing exercise) 5 days per week for 6 weeks at home.
干预措施: POWERbreathe Plus IMT (Device)
结局指标
主要结局
Adherence to treatment protocol
时间窗: 6 weeks
Number of sets and repetitions of training breaths completed during the 6-week inspiratory muscle training protocol
Percent completion
时间窗: 6 weeks
Percentage of enrolled participants who complete the 6-week inspiratory muscle training protocol
次要结局
- Maximal inspiratory pressure (measured in cm H2O)(6 weeks)
- Diaphragm thickness (measured in mm)(6 weeks)
- Exercise ventilation(6 weeks)
研究者
Simon Ho
Assistant Professor
University of Maryland, Baltimore