Evaluation of the effect of sildenafil plus melatonin on oxidative stress markers in polycystic ovarian syndrome patients who treated with metformin

Emam Sajad Yasouj Hospital0 个研究点目标入组 128 人开始时间: 待定最近更新: 2024年5月27日

试验速览

暂无简介。

•Patients aged 18 to 45 years
•Body mass index 19 to 25
•Presence of two of the following cases (according to the Rotterdam criteria): Findings of ultrasound sonography ,which was performed on the 10th day of the patient's last menstrual cycle (ovarian volume more than 10 ml or more than 12 follicles of 2 to 9 mm)
•Symptoms of hyperandrogenism: Clinical (hirsutism according to Freeman Galloway criteria more than 7 or acne) ,Laboratory (increasing the total testosterone level more than the standard value determined by the relevant laboratory) Oligomenorrhea (cycles longer than 35 days) or amenorrhea (absence of menstruation in the last 6 months)

•Patients who do not want to cooperate.
•Sildenafil sensitivity and intolerance to side effects (flushing, visual disturbances, severe drop in blood pressure and hearing disorders)
•Existence of severe mental conditions since 6 months before the research that has an adverse effect on the patient's quality of life, such as the death of a loved one, incurable illness in family members, change of residence, sudden loss of job or extensive surgery.
•Suffering from a severe degree of depression and anxiety according to the depression and anxiety questionnaire based on the Beck depression and anxiety questionnaire
•Current use of psychiatric medications
•Language or cognitive problems preventing the patient from completing the questionnaire

发起方

Emam Sajad Yasouj Hospital