Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 276
- 试验地点
- 2
- 主要终点
- glycemic control
研究概览
简要总结
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
详细描述
Most of exercise interventions involved aerobic exercises, investigators were not able to find a single long term study focusing on type 2 diabetes prevention with resistance training and aerobic exercise. It has been known that for those who have already had diabetes, resistance training can reduce insulin resistance and HbA1c level, improve lipid profile, and decrease blood pressure. Based on previous findings, investigators will evaluate how the different exercising interventions impact on insulin resistance, metabolic control, and the incidence and prevalence of diabetes in prediabetes population who receive 12 months of either resistant training or aerobic exercise. Further more, metabolomics approach will be introduced to detect biological markers,and therefore,to analyze the predictive values of metabolomics on long term outcomes of prediabetes population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a confirmed diagnosis of prediabetes according to the American Diabetes Association (ADA) guidelines
- •level 4 of muscle strength
- •willingness to accept exercise intervention
- •provision of written informed consent.
排除标准
- •type 2 or other types of diabetes
- •women who are pregnant
- •hepatic dysfunction, as evidenced by alanine aminotransferase (ALT) or alkaline phosphatase (ALP) levels greater than 2.5-fold the upper limits of normal
- •crucial organ failure or other severe diseases, including myocardial infarction
- •malignancy
结局指标
主要结局
glycemic control
时间窗: 12 months
Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 12 months.
次要结局
- small molecule metabolites(12 months)
- Incidence rate of diabetes(12 months)
研究者
Lou Qingqing
director, department of education
Nanjing University of Traditional Chinese Medicine