Effects of a Freeze Dried Strawberry Powder on Postprandial Vascular Function and Blood Markers of Cardiovascular Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Change from baseline in postprandial central blood pressure and arterial stiffness
研究概览
简要总结
It is important to identify and evaluate foods, such as strawberries, that can improve established and emerging cardiovascular risk factors, such as postprandial lipid and glycemic responses, and vascular health. Postprandial derangements may affect multiple metabolic pathways that lead to increased arterial stiffness. Research has demonstrated the potential of strawberries to ameliorate postprandial responses to a high fat/high glucose meal. Further research is needed to demonstrate this effect in better controlled clinical studies and explore whether metabolic effects lead to improved arterial health.
The investigators propose to examine the effects of adding 40 g of freeze-dried strawberry powder to a high fat/high glucose meal on postprandial cardiovascular risk factor including lipids, insulin, glucose, and arterial stiffness and central blood pressure. The investigators hypothesize that the bioactive components of strawberry powder will attenuate postprandial lipemic and glycemic responses, as well as improve measures of arterial health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20-50 years of age
- •LDL-C below 160 mg/dL
- •Triglycerides below 350 mg/dL
- •No stage II hypertension (BP below 160/100 mmHg)
- •Not taking medication for elevated lipids, blood pressure, or glucose
排除标准
- •Allergies to strawberries
- •Known intolerance to high fat meals
- •History of cardiovascular disease, kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis
- •Use of non-steroidal anti-inflammatory or immunosuppressant drugs
- •Conditions requiring the use of steroids
- •Use of medication or supplements for elevated lipids, blood pressure or glucose
结局指标
主要结局
Change from baseline in postprandial central blood pressure and arterial stiffness
时间窗: 2 and 4 hours
次要结局
- Postprandial changes in insulin(0, 0.5, 1, 2, and 4 hours)
- Postprandial changes in markers of inflammation/oxidative stress(0, 0.5, 1, 2, and 4 hours)
- Postprandial changes in glucose(0, 0.5, 1, 2, and 4 hours)
- Change from baseline in postprandial triglycerides at 0.5, 1, 2, and 4 hours(0.5, 1, 2, and 4 hours)