Restrictive vs Liberal fluid management in sepsis induced hypotension

This is a prospective  randomized study to compare restrictive vs liberal fluid management in patient undergoing sepsis induce hypotension.A total number of 364 patient were enrolled in the study presenting to the CCU and will be randomized onto two two groups through sealed envelope techniques .Group A  with 182 patient receiving vasopressor as noradrenaline 5 ampoule till MAP is maintained greater than 65 mmHg Patient will be reassessed after one hour and if MAP is not maintain second vasopressor  as Vasopressin at the rate 2.4 ml/hour will be started and will be assessed till one hour. In Group B with 182 patient will receive 2 liters of bolus fluid over 1 hour followed by 2 liters over next 4 hour to maintain MAP >65 mmHg Primary outcome will be measured as Death from any cause brfore discharge or by day 90 and secndary outcomes measured will be in terms of days free from ventilator use,days free from renal replacement therapy,days free from vasopressor use, days out of CCU.