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临床试验/NCT02564601
NCT02564601已完成不适用

The Impact of Piano Training on Cognitive Performance and Psychosocial Well-Being in Older Adults

University of South Florida2 个研究点 分布在 1 个国家目标入组 93 人开始时间: 2015年6月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
93
试验地点
2
主要终点
Trail Making Test

研究概览

简要总结

This project evaluates the effects of piano training and computerized cognitive training on cognitive performance in healthy older adults compared to controls. The project is intended for healthy older adults (60-80 years) with little to no previous musical training (less than three years of prior musical training or cognitive training and not currently engaged in music reading or musical performance, less than 10 hours of previous cognitive training). Investigators anticipate that musical engagement will serve as an enjoyable cognitive intervention for older adults. Investigators believe that piano training will enhance cognitive performance on executive functions essential for maintaining independence in older adulthood. Learning a musical instrument, while challenging, will improve self-efficacy, mood, and qualtiy of life. Participants engaged in piano training will demonstrate reduced cortisol levels and increased immune function responses. Investigators predict that adults enrolled in computerized cognitive training will demonstrate enhanced memory, working memory and self-efficacy post-training.

详细描述

The project purpose is to scientifically examine the benefits of piano training as compared to computer cognitive training and no treatment controls on cognitive (processing speed, task-switching, verbal fluency, verbal memory, and working memory), psychosocial (mood, self-efficacy, and quality of life), and physiological variables (biomarkers) in healthy older adult participants in a randomized clinical trial design.

Participants: Ninety community dwelling older adults will be recruited from the community. Criteria for enrollment are: between the ages of 60-80, native English speakers, not currently taking medications affecting memory performance, have no pre-existing cognitive impairment or neurological disorders, (as indicated by the Telephone Interview for Cognitive Status > 30), no moderate to severe depression (as indicated by the Geriatric Depression Scale), no difficulty with hand movements, less than three years of prior musical training, not currently engaged in music reading or musical performance, and less than ten hours of prior computer brain training experience. Participants will be randomly assigned to one of three groups stratified by intelligence and gender: piano instruction, computerized cognitive training or a no treatment control group. Informed written consent will be obtained in accordance with the Institutional Review Board.

Procedure: Participants will be tested in three visits: pre-training, immediately post-training, and three months follow-up. Those randomized to piano training or computerized cognitive training will complete their assigned training between pre-training and post-training visits. Measures of music aptitude and intelligence will be administered at the pre-training visit. These factors can influence cognitive performance. Any significant differences at baseline between the three assigned groups will be statistically controlled for in the analyses. Standardized cognitive measures will be used to examine processing speed, task-switching, verbal fluency, verbal memory, and working memory at each visit. Psychosocial outcomes (mood, self-efficacy, and quality of life) and physiological biomarkers will also be evaluated at each visit.

The goal for both interventions will be to complete 48 hours of group training over a four month period (16 weeks). Sixty participants (30 piano training; 30 auditory computer training) will be asked to attend three hours of training each week. Thirty participants will serve in the no treatment control group. Piano training will consist of basic piano technique, dexterity exercises, piano literature, and music theory. Participants will be expected to perform all major scales, repertoire from the Alfred All-in-One Method, and complete weekly theory assignments. Each class session is structured as a cognitive intervention that focuses upon review of materials (15-20 min), and the remaining portion of the class focuses upon learning new skills and concepts. Computerized cognitive training involves computerized perceptual practice exercises that vary in difficulty ranging from basic auditory processing speed to application through memory exercises. Within each exercise, the stimuli (i.e., tones, speech sounds, words, sentences) become less discriminable and speed of presentation increases (making the exercises more difficult) as performance improves. The Brain Fitness training program with working memory exercises will be used.

Data source(s). Data will consist of a series of standardized cognitive, psychosocial, and neurophysiological measures administered at three time points: pre-training, post-training, and at a three month follow-up. All standardized measures have been previously used to assess the efficacy of cognitive training approaches and demonstrate good psychometric properties.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
60 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Between the ages of 60-80
  • native English speakers
  • no pre-existing cognitive impairment or neurological impairment
  • not taking medications affecting memory performance (sleep meds, antidepressants, etc.)
  • Telephone Interview for Cognitive Status (score >30)
  • no moderate to severe depression
  • no difficulty with hand movements
  • less than three years of formal music training
  • no difficulty with the movement of their hands
  • not currently engaged in music reading or musical performance
  • < 10 hours of previous cognitive training

排除标准

  • Those not between 60-80
  • those taking medications affecting memory performance
  • Non-Native English Speakers
  • Those with pre-existing cognitive impairment
  • Telephone Interview for Cognitive Status (score < 30)
  • Those with difficulty in the movement of their hands
  • Those with more than three years of formal music training or currently engaged in music reading or music performance
  • Those with more than ten hours of cognitive training

研究组 & 干预措施

A1 Piano Training

Experimental

16 weekly classes will be provided to the piano training group. Each piano class session will focus upon review of materials (15-20 min), and the remaining portion of the class will focus upon learning new skills and concepts. This course includes finger dexterity exercises, basic piano technique, and basic piano repertoire.

干预措施: Piano Training (Behavioral)

A2 Computer Cognitive Training

Experimental

16 weekly classes will be provided to the computerized cognitive training group. Computerized cognitive training involves process-based computerized practice of adaptive perceptual exercises. Each computer cognitive training class session will focus upon practice of cognitive exercises that vary in difficulty ranging from basic auditory processing speed to application through memory and working memory exercises. Within each exercise, the stimuli (i.e., tones, speech sounds, words, sentences) become less discriminable and speed of presentation increases (making the exercises more difficult) as performance improves.

干预措施: Computer Cognitive Training (Behavioral)

A 3 No Treatment Controls

No Intervention

No classes will be provided to our control group. This is a no-treatment control group.

结局指标

主要结局

Trail Making Test

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Planning and Processing Speed

Salivary Cortisol

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Stress Levels

SIgA levels

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Immune Function

Delis Kaplan Executive Function Verbal Fluency subtest

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Category Fluency, Letter Fluency, Category Switching

Cognitive Self-Report Questionnaire (25)

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Mood

General Self-Efficacy

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

General Self-Efficacy

N-Back

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Working Memory Measure in the Visual Domain

Cued Color Word Stroop

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Cognitive Control, Inhibition

Paced Auditory Serial Addition Task (PASAT)

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Complex processing speed

Finger Tapper Test

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Motor Speed

Musical Performance Self-Efficacy

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Musical Self-Efficacy

Digit Coding- WAIS IV subtest

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Simple Processing Speed

Symbol Search- WAIS IV subtest

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Visual Scanning

Rey Auditory Verbal Learning Test

时间窗: (CHANGE) up to 16 weeks and after study completion 7 months

Verbal Memory

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jennifer Bugos

Assistant Professor

University of South Florida

研究点 (2)

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